Low-dose naltrexone

No. LDN is a prescription medication — naltrexone, prescribed at a low dose. It requires licensed physician review and approval, and it's prepared by a licensed compounding pharmacy.

LDN stands for Low-Dose Naltrexone. It contains naltrexone at a much lower dose than its original approved use, typically around 4.5 mg. Research suggests that, at low doses, it may help regulate immune and inflammatory activity and may increase the body's production of natural endorphins.

No to both. LDN is not an opioid and is not considered addictive. It does not work by blocking pain signals or creating dependence. Instead, it appears to work by influencing immune and inflammatory pathways and may help regulate some of the underlying processes associated with pain, discomfort, and brain fog.

LDN is often prescribed off-label for conditions involving inflammation, chronic pain, fatigue, brain fog, sleep disturbances, and autoimmune dysfunction. Some people report improvements in symptoms and overall well-being, although results vary from person to person. LDN is not FDA-approved for these uses, and a licensed physician will determine whether it may be appropriate based on your medical history and treatment goals.

You complete a short, secure medical intake form. A U.S.-licensed physician reviews your information online. If treatment is medically appropriate, your prescription ships to your door. If you're not eligible for treatment, you'll receive a full refund. Every few months a follow-up evaluation is required to review your treatment plan and determine whether continued therapy is appropriate.

If you’re not approved, you will be refunded. The physician may explain why and suggest next steps.

LDN is generally well tolerated and has been used for many years in clinical practice. The low doses used in LDN are significantly lower than those used for standard naltrexone treatment, which may reduce the likelihood of side effects. As with any prescription medication, LDN is not appropriate for everyone and can cause side effects in some people. A licensed physician will review your medical history, medications, and health status to determine whether it is appropriate for you.

Tell your physician about everything you take, including prescription medications, over-the-counter drugs, and supplements. The most important rule is that LDN should not be used with opioid pain medications because naltrexone blocks the effects of opioids. Your physician will review your medications and medical history before approving treatment.

Side effects are usually mild and temporary. The most commonly reported effects are vivid dreams, changes in sleep patterns, headache, or mild stomach discomfort as the body adjusts. Your treatment is reviewed by a licensed physician, who can adjust the plan if needed based on your response and any side effects you experience.

Some people notice changes within a few weeks, while for others it takes longer. The dose is often adjusted gradually to find the right balance. Because responses vary, LDN is typically evaluated over several months, with full effects often assessed around the 3-month mark.

Lab work is usually (but not always!) optional. You can upload existing lab results or purchase a lab kit if you'd like baseline data before treatment. Some patients choose to track markers such as hs-CRP to monitor inflammation over time. Depending on your medical history and intake responses, the physician may request additional information before approving treatment.

Compounded LDN is typically not covered by insurance and is paid for out of pocket. Coverage varies by plan, so you'll need to check with your insurance provider for details about your specific benefits.

If approved by a physician, your prescription is prepared by Curexa, a licensed U.S. compounding pharmacy. Curexa is a PCAB-accredited pharmacy that compounds medications to physician specifications and operates under state pharmacy regulations and quality-control standards. Every prescription is reviewed, prepared, and dispensed by licensed pharmacy professionals before shipment.

Cancel anytime before your medication is dispensed. If your physician has already issued a prescription, a $35 physician consultation fee will be deducted from any refund.