The Science behind T·Time

Explore your testosterone care options

A short introduction—not a diagnosis or medical eligibility decision.

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What's your primary goal?

Feel energized every day

Build and maintain muscle

Improve mental clarity and focus

Support a long, healthy life

Symptoms and repeat morning blood tests guide a diagnosis—not age alone.

Source: Endocrine Society clinical practice guideline

Daily Energy

How would you rate your
current energy levels?

I feel good, but could improve

Average, sometimes tired

Always fatigued and need a change

In a small clinical study, enclomiphene increased testosterone within 2 weeks of treatment.

Source: Wiehle et al., BJU International (2013). Individual responses vary.

How long have you felt this way?

Less than a year

1–3 years

3–5 years

Over 5 years

Enclomiphene raised LH and FSH levels, supporting natural testosterone production.

Source: Wiehle et al., Fertility and Sterility (2014)

How important is your health to you?

It is key to my success

Somewhat important

I need to make it a priority

In 16-week trials, men receiving enclomiphene maintained sperm counts while testosterone gel reduced them. This does not guarantee fertility.

Source: Kim et al., BJU International (2016)

How are you currently supporting your health? (select all that apply)

I exercise regularly and eat well

I take supplements and track my progress

I follow a consistent exercise routine

I am on testosterone replacement therapy

I am looking for the right guidance to improve

Treatment Knowledge

How familiar are you with testosterone treatment?

Not familiar, I would like to learn the basics

I know a bit, but want a deeper understanding

I am informed and comparing treatment options

It's Time for T·TIME

Explore the plan, complete your medical intake and provide required labs. A licensed clinician decides whether to prescribe. If medically declined before a prescription is issued, treatment-program payments are refunded under our refund policy; labs, shipping and services already provided are excluded.

I'd Love to Get Started I Want to Learn More

An oral approach. A clinical decision.

Works through hormone signals

Enclomiphene can increase LH and FSH, the signals involved in testosterone and sperm production.

Discuss your fertility goals

Trials measured maintained sperm concentrations. That is not a guarantee of fertility or pregnancy.

Guided by your evaluation

Symptoms, medical history and blood tests help your clinician assess the cause and the treatment options.

Oral treatment, if prescribed

A tablet taken as directed by your clinician, without applying a gel or giving yourself an injection.

The Clinical Evidence

What the clinical trials found

Enclomiphene stimulates hormone signaling; testosterone gel supplies testosterone directly. Both approaches increased testosterone in the trials below, with different effects on LH, FSH and sperm concentration.

Key Study: Enclomiphene vs. Testosterone Gel (ZA-304/305 Trials)

Two 16-week Phase III trials included 256 men in the safety population with secondary hypogonadism. Researchers compared investigational oral enclomiphene with testosterone gel and placebo. These were not trials of T·TIME’s compounded product.

Metric	Enclomiphene Citrate	Topical Testosterone Gel
Total Testosterone Enclomiphene Citrate Increased on average Topical Testosterone Gel Increased on average	Increased on average	Increased on average
LH Levels (Pituitary Signal) Enclomiphene Citrate Increased (Pituitary signal) Topical Testosterone Gel Decreased (Pituitary signal)	Increased (Pituitary signal)	Decreased (Pituitary signal)
FSH Levels (Fertility Signal) Enclomiphene Citrate Increased (Pituitary signal) Topical Testosterone Gel Decreased (Pituitary signal)	Increased (Pituitary signal)	Decreased (Pituitary signal)
Sperm Concentration Enclomiphene Citrate Maintained on average Topical Testosterone Gel Decreased on average	Maintained on average	Decreased on average

Your care, step by step

A plan based on you—not a promised timeline

Hormone changes do not guarantee changes in how you feel. Your clinician reviews your symptoms, test results and response to decide whether treatment is appropriate and how to follow up.

Step 1

Build a clear baseline

Share your symptoms, medical history, medications and fertility goals. Diagnosis generally requires symptoms and consistently low morning testosterone results, with repeat testing and evaluation of the cause.

Step 2

Review your options

Your clinician considers whether treatment is appropriate, explains risks and alternatives, and chooses the medication and dose if prescribed. Not everyone with fatigue or a low test result needs the same treatment.

Step 3

Review your response

Follow the monitoring plan set by your clinician. Report side effects and changes in symptoms. Follow-up testing helps guide whether to continue, adjust or stop treatment; a higher testosterone number alone does not establish benefit.

Sources

Endocrine Society: diagnosing testosterone deficiency

FDA: understanding compounded medicines

PubMed (PMID: 26496621): Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement

Explore your options

Data Comparison

Two approaches to testosterone care

The right choice depends on your diagnosis, fertility goals, risks and preferences. Testosterone replacement is an established option for appropriate patients. Enclomiphene has a different mechanism and is not FDA-approved.

Feature	Enclomiphene Citrate (Oral)	Testosterone Injections (Shot)
Primary Action Enclomiphene Citrate (Oral) Stimulates natural production Testosterone Injections (Shot) Supplies testosterone from outside the body	Stimulates natural production	Supplies testosterone from outside the body
T-Level Peak Enclomiphene Citrate (Oral) Response varies by patient and dose Testosterone Injections (Shot) Pattern varies by formulation and schedule	Response varies by patient and dose	Pattern varies by formulation and schedule
LH/FSH Signal Enclomiphene Citrate (Oral) Increases (Observed in trials) Testosterone Injections (Shot) Suppresses (Negative feedback)	Increases (Observed in trials)	Suppresses (Negative feedback)
Fertility Enclomiphene Citrate (Oral) Sperm concentration maintained in trials; fertility not guaranteed Testosterone Injections (Shot) Significant risk of suppression	Sperm concentration maintained in trials; fertility not guaranteed	Significant risk of suppression
After stopping Enclomiphene Citrate (Oral) Long-term persistence of benefit is not established Testosterone Injections (Shot) Response depends on preparation and clinical factors	Long-term persistence of benefit is not established	Response depends on preparation and clinical factors

TEST YOURSELF

Not feeling like yourself? Start with an evaluation.

Low energy, changes in sex drive and reduced strength can have many causes. These experiences can be worth discussing with a clinician; they do not diagnose low testosterone or establish eligibility for medication.

The 3 PM Wall

You find yourself reaching for a third cup of coffee just to survive the workday, yet you still feel "wired but tired" at night.

The "Soft" Plateau

You’re putting in the work at the gym, but your body isn't responding. Recovery takes longer, and stubborn midsection weight is becoming harder to shift.

The Mental Fog

That sharp, decisive "edge" you used to have in meetings or during complex tasks feels like it’s been replaced by a persistent mental haze

Vanishing Drive

It’s not just about the bedroom—it’s a general lack of "get-up-and-go" for your hobbies, your career, and your social life.

Your treatment preferences

If injections or future fertility are concerns, discuss them with your clinician when comparing treatment options.

The next step

A medical evaluation can help explain your symptoms. Your clinician reviews your history and lab results before deciding whether any treatment is appropriate.

Explore your options

Start with a short questionnaire. Clinical eligibility requires medical review and lab results.

Care starts with a medical review

Understand your options with a licensed clinician.

Complete your intake from home. Your clinician reviews the information needed to decide whether prescription treatment is appropriate.

The T·TIME care process:

Medical intake

Complete a secure medical questionnaire from home.

Physician review & prescription

A licensed U.S. clinician reviews your intake and required labs before deciding whether to prescribe.

Start
Treatment

If prescribed, your medication is prepared by a licensed pharmacy and shipped to you.

Start your plan

Illustration of two orange T·TIME enclomiphene tablets

Oral Enclomiphene Rx

Full 90-Day Supply Shipped Upfront

$2.3

/ day equivalent. $207 billed for 90 days.

CLICK TO REVIEW

Plan details:

Same plan price for every prescribed strength. Required labs are separate.

Blood tests required to begin.

90-Day Treatment Plan, Delivered Quarterly.

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In a six-week study, 12 men taking 25 mg daily had mean testosterone of 604 ng/dL. This small subgroup does not predict individual results.*

Source: Wiehle et al., BJU International (2013).

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What to know before treatment

Prescription required. A licensed clinician reviews your symptoms, medical history and lab results to determine whether treatment is appropriate.
Enclomiphene is not FDA-approved. Compounded drugs are not reviewed by FDA for safety, effectiveness or quality before marketing.
Evidence has limits. Trials measured hormone levels and sperm concentrations. Benefits for symptoms, pregnancy outcomes and long-term health remain uncertain.
Treatment has risks. Side effects can occur, and serious risks including blood clots have been reported. Discuss risks, alternatives and fertility goals with your clinician.
‍Contact your clinician promptly about new vision changes or other concerning symptoms. Seek urgent medical care for symptoms of a possible blood clot, such as chest pain, trouble breathing or one-sided leg swelling.

Understand the evidence and your care

Enclomiphene has been studied in men with secondary hypogonadism. Published studies describe specific study populations and formulations; they do not establish the safety or effectiveness of every compounded preparation.

Read the 2016 randomized trials and 2013 clinical study, or explore our study summaries and questions.

For the practical next steps, see enclomiphene care and pricing, how T·TIME works, and our clinical, pharmacy and laboratory partners.

Sources checked October 26, 2026. Educational content from T·TIME; individual treatment decisions belong to your licensed clinician.

Explore your testosterone care options

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It's Time for T·TIME

Tune Your Internal Engine